THE CURRENT STATE OF VIRTUAL AUTOPSY USING INTEGRATED VISUALIZATION TECHNOLOGIES
Relevance. Virtual autopsy is positioned as a non-invasive method of postmortal examination, which provides objectively verifiable forensic data without the need for a traditional autopsy.
The aim of this study was to evaluate the diagnostic value of virtual autopsy (virtopsy) as an alternative to traditional medical autopsy in patients undergoing intensive care in the anesthesiology intensive care unit (ICU).
Materials and methods: Study design: Prospective study. Multidetector computed tomography (MDCT), magnetic resonance imaging (MRI), 3D image reconstruction, and histological assessment performed under the supervision of certified specialists. Diagnostic data from virtual autopsy were compared with clinical diagnoses and the results of traditional forensic examination, which allowed us to evaluate the accuracy and completeness of the identified pathologies.
Results: Virtual autopsy confirms 88% of clinical diagnoses and identifies additional pathologies, such as hemorrhages, strokes, and pneumothorax, including changes that could be missed during a traditional autopsy. These findings demonstrate the high diagnostic efficacy of the method, its practical value for improving the accuracy of postmortem diagnostics, and expanding capabilities in forensic and clinical fields. Overall, the study demonstrates the potential of virtual autopsy as a promising non-invasive tool in modern medicine.
Conclusions: The study confirmed the feasibility of using virtual autopsy as an effective complement to and temporary replacement for traditional autopsy, contributing to the development of modern postmortem diagnostic methods and improving the quality of medical examinations in both forensic and clinical fields.
Kulsara Rustemova– Doctor of medical science, professor at the Department of Surgical Disciplines, NCJSC ““Kokshetau University after named Sh. Ualikhanov”, Kokshetau, Republic of Kazakhstan; е-mail: rustemovakr@gmail.com; Cell phone: + +77752810690; ORCID: https://orcid.org/0000-0002-8853-9267;
Aibota Abutalipova – 1st-year intern at the Department of Surgical Disciplines, General Medicine, NCJSC “Kokshetau University after named Sh. Ualikhanov”, Kokshetau, Republic of Kazakhstan; е-mail: aibota713@gmail.com; Cell phone: +7705 645 8098; ORCID: https://orcid.org/0009-0003-2402-6117;
Marat Syzdykbayev – Doctor of medical science, professor at the Department of Anesthesiology and Resuscitation, NCJSC “Semey Medical University”, Semey, Republic of Kazakhstan; е-mail: Марат Сыздыкбаев marat.syzdykbayev@smu.edu.kz; Cell phone: +77776334757; ORCID: https://orcid.org/my-orcid?orcid=0000-0002-0561-4111
Bazar Tuleuov – Head of Department of Surgery, Emergency Hospital Semey, Republic of Kazakhstan; е-mail: bazar tuleuov@mail.ru; Cell phone: +7 701 918 0060; ORCID: https://orcid.org/my-orcid?orcid=0009-0007-9660-1220
Gulshat Alimkhanova Head of Department of Anesthesiology, NJSC Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan; a.gulya83@mail.ru ; +7 701 795 7579; https://orcid.org/0000-0001-7304-9102
*Corresponding author:
Marzhan Nurkenovna Myrzakhanova – Candidate of medical science, Professor at the Department of Surgical Disciplines, Non-Profit Joint-Stock Company “Kokshetau University after named Sh. Ualikhanov”, Kokshetau, Republic of Kazakhstan. ORCID: https://orcid.org/0000-0002-6301-7040;
Address: Republic of Kazakhstan, 020000, Akmola Region, Kokshetau city, Abai st,76.
E-mail: mmarzhan269@gmail.com
Phone: +77474523020
Ayoub T., Chow J. The conventional autopsy in modern medicine. J R Soc Med. 2008 Apr;101(4):177-81. Doi: 10.1258/jrsm.2008.070479. PMID: 18387908; PMCID: PMC2312379.
2. Aghayev E., Sonnenschein M., Jackowski C., Thali M., Buck U., Yen K., et al. Postmortem radiology of fatal hemorrhage: measurements of cross-sectional areas of major blood vessels and volumes of aorta and spleen on MDCT and volumes of heart chambers on MRI. AJR Am J Roentgenol. 2006; 187:209-15. [PMID:16794178]
3. Aghayev E., Ebert L.C., Christe A., Jackowski C., Rudolph T., Kowal J., et al. CT data-based navigation for post-mortem biopsy-a feasibility study. J Forensic Leg Med. 2008;15:382-7. [PMID: 18586209]
4. Burton J.L., Underwood J. Clinical, educational, and epidemiological value of autopsy. Lancet. 2007 Apr 28;369(9571):1471-1480. Doi: 10.1016/S0140-6736(07)60376-6. PMID: 17467518.
5. Britt M. Blokker, Ivo M. Wagensveld, Annick C. Weustink, Wolter J. Oosterhuis, M.G. Myriam Hunink. Non-invasive or minimally invasive autopsy compared to conventional autopsy of suspected natural deaths in adults: a systematic review. Eur Radiol. 2015 Jul 27; 26:1159–1179. Doi: 10.1007/s00330-015-3908-8.
6. Bolliger S.A., Thali M.J., Ross S., Buck U., Naether S., Vock P. Virtual autopsy using imaging: bridging radiologic and forensic sciences. A review of the Virtopsy and similar projects. Eur Radiol. 2008; 18:273-82. [PMID: 17705044]
7. Bisset R.A., Thomas N.B., Turnbull I.W., Lee S. Postmortem examinations using magnetic resonance imaging: four-year review of a working service. BMJ. 2002; 324:1423-4. [PMID: 12065265]
8. Carbot R. Diagnostic pitfalls identified during a study of three thousand autopsies. JAMA. 1912; 59:2295-8. 1
9. Christe A., Ross S., Oesterhelweg L., Spendlove D., Bolliger S., Vock P., et al. Abdominal trauma—sensitivity and specificity of postmortem noncontrast imaging findings compared with autopsy findings. J Trauma. 2009; 66:1302-7. [PMID: 19430230]
10. De Vlieger G.Y., Mahieu E.M., Meersseman W. Clinical review: what is the role for autopsy in the ICU? Crit Care. 2010; 14:221. [PMID: 20565845]
11. O’Grady G. Death of the teaching autopsy. BMJ. 2003; 327:802-3. [PMID: 14525883]
12. Gaensbacher S., Waldhoer T., Berzlanovich A. The slow death of autopsies: a retrospective analysis of the autopsy prevalence rate in Austria from 1990 to 2009. Eur J Epidemiol. 2012 Jul;27(7):577-80. Doi: 10.1007/s10654-012-9709-3. Epub 2012 Jun 27. PMID: 22736188.
13. Levy A.D., Abbott R.M., Mallak C.T., Getz J.M,. Harcke H.T., Champion H.R, et al. Virtual autopsy: preliminary experience in high-velocity gunshot wound victims. Radiology. 2006; 240:522-8. [PMID: 16801370]
14. Richard Dirnhofer et al. (2006). VIRTOPSY: minimally invasive, imaging-guided virtual autopsy. Radiographics 2006 Sep-Oct;26(5):1305-33. Doi: 10.1148/rg.265065001 URL: https://pubs.rsna.org/doi/full/10.1148/rg.265065001.
15. Romica Cergan, Iulian Alexandru Taciuc, Mihai Dumitru, Daniela Vrinceanu, Felicia Manole, Nicoleta Sanda, Andreea Nicoleta Marinescu. The Current Status of Virtual Autopsy Using Combined Imaging Modalities: A Scoping Review, J Clin Med. 2025 Jan 25;14(3):782. Doi: 10.3390/jcm14030782. URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC11818485/
16. Shojania K.G., Burton E.C. The vanishing nonforensic autopsy. N Engl J Med. 2008 Feb 28;358(9):873-5. Doi: 10.1056/NEJMp0707996. PMID: 18305264].
17. Staicu A., Albu C., Popa-Stanila R., Bondor C., Chiriac L., Eniu D., Goidescu I., Florian A.R., Surcel M., Cruciat G., Muresan D., Rotar I. Whole-body non-forensic fetal virtopsy using postmortem magnetic resonance imaging at 7 Tesla vs classical autopsy. https://doi.org/10.1002/uog.29106.
18. Shojania KG, Burton EC, McDonald KM, Goldman L. Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. JAMA. 2003; 289:2849-56. [PMID: 12783916]
19. Saunders S.L., Morgan B., Raj V., Rutty G.N. Post-mortem computed tomography angiography: past, present and future. Forensic Sci Med Pathol. 2011;7: 271-7. [PMID: 21153718]
20. Thali M.J., et al. (2003). Virtopsy-a new imaging horizon in forensic pathology: virtual autopsy by postmortem multislice computed tomography (MSCT) and magnetic resonance imaging (MRI)—a feasibility study. Journal of Forensic Sciences, 48(2), 386-403.DOI:10.1520/JFS2002166 URL:https://pubmed.ncbi.nlm.nih.gov/12665000/
21. Veress B., Alafuzoff I. Clinical diagnostic accuracy audited by autopsy in a university hospital in two eras. Qual Assur Health Care. 1993; 5:281-6. [PMID:8018882]
22. World Health Organization. International Classification of Diseases (ICD) 10th Edition. Geneva: World Health Organization; 2010.
23. Weustink A.C., Hunink M.G., van Dijke C.F., Renken N.S., Krestin G.P., Oosterhuis J.W. Minimally invasive autopsy: an alternative to conventional autopsy? Radiology. 2009; 250:897-904. [PMID: 19244053]
24. Wichmann D., Scherpe S., Heese O., Schmiedel S., Burchard G.D., Ruckdeschel K., et al. If the rumor is tumor, the issue is tissue [Letter]. Neurosurgery. 2008;63:E820. [PMID: 18981853]
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Myrzakhanova M.N., Rustemova G.R., Abutalipova A.D., Syzdykbayev M.K., Tuleuov B.M., Alimkhanova G.N. Current state of virtual autopsy using integrated visualization technologies // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (5), pp. 112-119. doi 10.34689/SH.2025.27.5.014Похожие публикации:
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